胆管癌是消化系统常见的恶性肿瘤,起病隐匿,恶性程度高,随着影像学技术的发展及临床上对此病的重视,报道发病率逐渐增高。胆管癌切除率低、预后差,这与不能早期发现有直接原因。如能找到有代表性的、高诊断价值的胆管癌肿瘤标记物,尤其是存在于血清中的标记物,对胆管癌的早期诊 Cholangiocarcinoma is a common malignant tumor of the digestive system, occult onset, high degree of malignancy, with the development of imaging technology and clinical emphasis on the disease, the reported incidence gradually increased. Cholangiocarcinoma resection rate is low, the prognosis is poor, which can not be found early and have a direct cause. If you can find a representative, high diagnostic value of cholangiocarcinoma tumor markers, especially in serum markers, the early diagnosis of cholangiocarcinoma