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目的:探讨地黄管食通口服液对食管癌放疗后大鼠的作用机制。方法:采用甲基戊基亚硝胺(MA-NA)皮下注射(5mg/kg)诱发的大鼠食管癌模型,大鼠食管局部钴60照射后,分别给予相应的受试药物5周。实验结束后采血清并应用酶联免疫吸附法(ELISA)检测血清中细胞因子TGF-α的含量。结果:地黄管食通口服液有抑制细胞因子TGF-α过度表达的作用。结论:地黄管食通口服液可能通过修复受损间质细胞,从而调节间质细胞分泌细胞因子的功能,起到抑制肿瘤细胞增殖复发的作用。
Objective: To explore the mechanism of radix rehmanniae decoction oral liquid on rats after esophageal cancer radiotherapy. Methods: The rat esophageal cancer model induced by subcutaneous injection of methyl pentylnitrosamine (MA-NA) (5mg / kg) was given. The rats were orally administered with cobalt 60 for 5 weeks. At the end of the experiment, serum was collected and the level of cytokine TGF-α in serum was detected by enzyme-linked immunosorbent assay (ELISA). Results: Dihuang Guan Shi Tong oral solution can inhibit the over-expression of cytokine TGF-α. Conclusion: Dihuang Guan Shi Tong oral liquid may repair the damaged interstitial cells, and regulate the function of interstitial cells to secrete cytokines, thus inhibiting the proliferation and recurrence of tumor cells.