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目的 探讨密钙息合并介入治疗骨转移癌的临床疗效。方法 对 42例骨转移癌患者采用密钙息针剂10 0IU肌注 ,每日 1次 ,连用 7天为 1疗程。同时对全组病人采用经皮骨转移病灶供血动脉插管化疗药物灌注 ,每 2 0～3 0天介入治疗 1次。结果 全组 42例共用密钙息 1疗程 2 8例 ,2疗程 8例 ,3疗程 5例 ,4疗程 1例。CR 4例 ,PR 2 8例 ,止痛有效率为 (CR +PR) 76 .1% ( 3 2 /4 2 )。治疗前活动能力Ⅰ级 +Ⅱ级为 17例 ,治疗后为 2 9例 ,活动能力有效率为70 .5 % ( 12 /17)。 42例病人介入治疗前共有骨转移灶总数 16 8个 ,介入治疗共进行 14 7例次 ,每例平均 3 .5次 ,治疗后病灶总数减为 14 7个 ,参照实体疗效标准统计CR 6例 ,PR 14例 ,总有效率 (CR +PR)为 47.6 % ( 2 0 /4 2 )。结论 密钙息与骨转移灶供血动脉介入化疗对中晚期骨转移癌 ,既能明显缓解骨癌造成的剧痛 ,同时使转移灶缩小 ,不失为晚期骨转移癌一种有效治疗手段。
Objective To explore the clinical efficacy of Mi-Ca-Cate combined with interventional treatment of bone metastases. Methods Forty-two patients with bone metastases were treated with intramuscular injection of 100 mg of calcium-dense calcium once daily for 7 days for one course of treatment. At the same time, all the patients were treated with transcatheter arterial chemoembolization via transcutaneous bone metastases and interventional therapy every 20-30 days. Results The whole group of 42 patients received a total of 28 courses of calcipine treatment, 8 courses of 2 courses, 5 courses of 3 courses and 1 case of 4 courses. CR 4 cases, PR 2 8 cases, analgesic effective rate (CR + PR) 76.1% (3 2/4 2). Pretreatment activity class Ⅰ + Ⅱ grade was 17 cases, 29 cases after treatment, activity ability was 70.5% (12/17). The total number of bone metastases in 42 patients before interventional therapy was 16.8. Interventional treatment was performed in 147 cases, with an average of 3.5 times in each case. The total number of lesions after treatment was reduced to 14.7. , PR 14 cases, the total effective rate (CR + PR) was 47.6% (20/42). Conclusions Mi close calcification and bone metastases for arterial infusion chemotherapy for advanced bone metastases, can significantly ease the pain caused by bone cancer, while reducing the metastasis, after all, an effective treatment for advanced bone metastases.