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结直肠癌缺失(deleted in colorectal carcinoma,DCC)基因是于1990年确定并命名的重要的肿瘤抑癌基因,定位于人染色体18q21.3。DCC蛋白具有跨膜分子特征,其胞外部分氨基酸排序与神经细胞黏附分子相似。细胞黏附分子介导细胞间、细胞与基质间的相互作用,促进细胞与细胞间的黏附,
The deleted-in colorectal carcinoma (DCC) gene was identified as an important tumor suppressor gene in 1990 and located on human chromosome 18q21.3. DCC protein has a transmembrane molecular features, the extracellular part of the amino acid sequence and neural cell adhesion molecules similar. Cell adhesion molecules mediate the intercellular, cell-matrix interactions and promote cell-cell adhesion,