论文部分内容阅读
A.历史背景对小鼠肝炎病毒的认识要回溯到在做EDIM病毒流行病学实验过程中那种叫做JHM的自然发生的嗜神经性小鼠病毒分离出来之时。JHM病毒感染的最明显特征是广泛的髓鞘破坏,不管是否为肠外途径接种。在一些组织中出现引人注目的巨细胞,肝脏出现灶性坏死区。幼龄大鼠、棉鼠和仓鼠大脑内接种时也易感。此后,另一些学者在各种情况下分离出许多和JHM不同、彼此之间主要在致病性上不同的致病因子。甚至现在,新的和那些已描述过的毒株在毒力、组织亲合性、宿主范围、免疫力方面相似或不同的毒株还可出
A. Historical Background The understanding of mouse hepatitis virus dates back to the time when the naturally occurring neurotropic mouse virus called JHM was isolated during the EDIM virus epidemiology experiment. The most noticeable feature of JHM virus infection is extensive myelin sheath disruption, regardless of whether it is parenteral. In some organizations, dramatic giant cells appear, and there are focal necrotic areas in the liver. Young rats, cotton rats and hamsters are also susceptible to inoculation in their brains. Since then, other scholars have isolated, in many cases, many different virulence factors that are different from JHM and predominantly pathogenic to each other. Even now, strains of new and those already described have similar or different virulence, tissue affinity, host range, immunity,