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目的：观察尿毒症血液透析（血透）患者血浆血小板相关抗体ＩｇＧ（ＰＡＩｇＧ）的变化及其对出血并发症的影响。方法：使用酶联免疫吸附法检测１７例尿毒症患者血透前、后血浆ＰＡＩｇＧ的含量。结果：尿毒症患者透析后血小板计数〔（９．１４±３．８２）×１０９／Ｌ〕较透析前〔（８．６３±３．６５）×１０９／Ｌ〕升高，血小板聚集率较正常参考值明显降低（Ｐ均＜０．０１）；尿毒症患者血浆ＰＡＩｇＧ较正常参考值显著增高，透析后血浆ＰＡＩｇＧ〔（４６．８±３５．９）ｎｇ／１０７ＰＡ〕较透析前〔（６２．４±４６．８）ｎｇ／１０７ＰＡ〕明显降低（Ｐ＜０．０１），但仍高于正常参考值。结论：血浆ＰＡＩｇＧ增高并非血小板减少的主要原因。血小板的功能不能充分发挥，血小板的内在缺陷是出血并发症的重要原因之一。测定血浆ＰＡＩｇＧ可为尿毒症出血并发症的防治提供参考依据。
Objective: To observe the changes of plasma platelet-related antibody IgG (PAIgG) in uremic hemodialysis (hemodialysis) patients and its effect on bleeding complication. Methods: The contents of plasma PAIgG in 17 patients with uremia before and after hemodialysis were detected by enzyme-linked immunosorbent assay. Results: The platelet count (9.14 ± 3.82) × 109 / L after dialysis in uremic patients was higher than that before dialysis (8.63 ± 3.65) × 109 / L), and the rate of platelet aggregation was higher than that of normal (P <0.01). PAIgG in plasma of patients with uremia was significantly higher than that of the normal reference value. After the dialysis, plasma PAIgG (46.8 ± 35.9) ng / 107PA was significantly higher than that before dialysis (62. 4 ± 46.8 ng / 107 PA] was significantly lower (P <0.01), but still higher than the normal reference value. Conclusion: The increase of plasma PAIgG is not the main reason of thrombocytopenia. Platelet function can not give full play to the intrinsic defects of platelets is one of the important causes of bleeding complications. Determination of plasma PAIgG can provide a reference for the prevention and treatment of uremic bleeding complications.