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目的:观察新生儿缺氧缺血性脑病(HIE)患儿血清可溶性细胞的水平,探讨其在HIE治疗中的临床意义。方法:采用双抗体夹心ELISA检测65例HIE患儿血清sICAM-1、TNF-α和S100B蛋白的水平,其中轻度23例,中度17例,重度25例,并与35例正常新生儿对照,采用方差分析进行统计学处理。结果:两组新生儿sICAM-1、TNF-α和S100B水平比较,差异有统计学意义(P<0.01),HIE轻、中、重组患儿血清sICAM-1、TNF-A和S100B水平随HIE程度加重而增加,组间比较,差异均有统计学意义(P<0.01)。结论:sICAM-1、TNF-α和S100B蛋白在HIE的发病机制中起着重要作用。
Objective: To observe the level of serum soluble cells in neonates with hypoxic-ischemic encephalopathy (HIE) and to explore its clinical significance in the treatment of HIE. Methods: Serum levels of sICAM-1, TNF-α and S100B in 65 children with HIE were detected by double antibody sandwich ELISA. Among them, 23 were mild, 17 were moderate and 25 were severe, and were compared with 35 normal neonates , Using ANOVA for statistical analysis. Results: The levels of sICAM-1, TNF-α and S100B in two neonates were significantly different (P <0.01). The levels of sICAM-1, TNF- The degree increased and increased, between groups, the differences were statistically significant (P <0.01). Conclusion: sICAM-1, TNF-α and S100B proteins play an important role in the pathogenesis of HIE.