糖尿病肾病（DN）早期常缺乏明显临床表现。一旦发现，患者肾功能常已进入难以治愈的中晚期，因此DN早期诊断尤为重要。目前临床上早期诊断肾脏疾病通常借助于ALB‘TRF、IgG等尿微量蛋白，以及常规检测，由于敏感性太低，大多数早期肾脏损害（尤其是早期的肾小管损害）往往不能 Early diabetic nephropathy often lack significant clinical manifestations. Once found, patients with renal function often has entered a difficult to cure in the late, so early diagnosis of DN is particularly important. Currently, early diagnosis of kidney disease in clinic is usually based on the use of microalbuminuria such as ALB’TRF and IgG, as well as routine testing. Due to the low sensitivity, most early kidney damage (especially early tubular damage) often can not