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拉西地平(lacidipine)是一种二氢吡啶类钙通道阻滞剂。据报道,健康人口服拉西地平2～5mg可使外周血管阻力降低,同时心率和搏出容量出现补偿性增高,其作用持续时间长于硝苯啶。作者用非损伤性实验方法研究了拉西地平对全身血管和颈动脉血管的扩张作用。试验采用双盲、随机、交叉方案。给予10例健康志愿者单剂拉西地平4mg或安慰剂口服,每一停药间隔期为7天。试验用半自动测定装置每15分钟测血压一次,用ECG连续监测仪测定心率,用脉冲式多普勒流量
Lacidipine is a dihydropyridine calcium channel blocker. It is reported that healthy people oral lacidipine 2 ~ 5mg can reduce peripheral vascular resistance, while compensatory increase in heart rate and stroke volume, its duration longer than nifedipine. The authors used noninvasive experimental methods to investigate the effects of lacidipine on the expansion of whole blood vessels and carotid arteries. Test using double-blind, random, cross-program. Ten healthy volunteers were given a single dose of lacidipine 4mg or placebo orally, each withdrawal interval of 7 days. Test semiautomatic determination of blood pressure every 15 minutes once, with ECG continuous monitor heart rate, with pulsed Doppler flow