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目的探讨蛋白酶活化受体2(PAR-2)在宫颈鳞癌及原位癌中的表达及意义。方法采用免疫组织化学SP法检测PAR-2在70例宫颈鳞癌,20例原位癌和15例正常宫颈组织中的表达。结果PAR-2在宫颈癌组织中的阳性表达率明显高于正常宫颈组织中的表达率(45.71%vs.0%,P<0.01);宫颈癌组织中PAR-2的阳性表达率随着临床期别及病理分级呈递增趋势。有盆腔淋巴结转移的宫颈癌组PAR-2阳性表达率为72.41%,显著高于无淋巴结转移组的26.83%(P<0.01)。结论PAR-2与宫颈癌的侵袭和淋巴转移密切相关。
Objective To investigate the expression and significance of protease-activated receptor 2 (PAR-2) in cervical squamous cell carcinoma and carcinoma in situ. Methods The expression of PAR-2 in 70 cases of cervical squamous cell carcinoma, 20 cases of carcinoma in situ and 15 cases of normal cervical tissue were detected by immunohistochemical SP method. Results The positive expression rate of PAR-2 in cervical cancer tissues was significantly higher than that in normal cervical tissues (45.71% vs.0%, P <0.01). The positive expression rate of PAR-2 in cervical cancer tissues was significantly higher than that in clinical The stage and pathological grade showed an increasing trend. The positive rate of PAR-2 in cervical cancer with pelvic lymph node metastasis was 72.41%, which was significantly higher than that in non-lymph node metastasis (26.83%, P <0.01). Conclusions PAR-2 is closely related to the invasion and lymphatic metastasis of cervical cancer.