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目的探讨宁夏地区2型糖尿病(T2DM)患者抑郁现状分布情况及其与血清尾加压素Ⅱ(UⅡ)、糖化血红蛋白(HbA_(1C))的相关性。方法选取宁夏地区宁夏南、北部山区和银川市城市社区1 208例不同性别、年龄段、文化程度、经济水平的T2DM患者,采用SDS抑郁自评量表对其是否有抑郁状况进行定量评估,研究不同人口学特征T2DM患者的抑郁状况,对不同抑郁状况下的T2DM人群进行有针对性的心理干预。用放射免疫法测定患者血浆中UⅡ的水平,用BioRADD10全自动糖化血红蛋白仪对其血浆HbA_(1C)水平进行测定,对比不同人口学特征T2DM患者体内UⅡ、HbA_(1C)的差异及其与抑郁状况之间的关系。结果女性T2DM患者的抑郁症状标准分值显著高于男性患者(P<0.05),低龄区段T2DM患者的抑郁标准得分显著高于高龄区段(P<0.05),文盲T2DM患者的抑郁标准得分显著高于其他文化程度区段(P<0.05),肥胖T2DM患者抑郁标准分显著高于正常体质量T2DM患者(P<0.05)。女性T2DM患者的血浆UⅡ水平显著高于男性患者(P<0.05),抑郁组血浆UⅡ和HbA_(1C)水平均显著高于非抑郁组(P<0.05)。T2DM患者血浆UⅡ和HbA_(1C)水平与抑郁症之间的相关分析表明,UⅡr=0.41,HbA_(1C)r=0.39(P<0.05)。结论不同人口学特征T2DM患者的抑郁状况分布可能存在较大差异,其抑郁程度与血浆中UⅡ和HbA_(1C)水平可能呈正相关性。
Objective To investigate the distribution of depression in type 2 diabetes mellitus (T2DM) patients in Ningxia and its relationship with urotensin Ⅱ (UⅡ) and glycosylated hemoglobin (HbA_ (1C)). Methods A total of 1 208 T2DM patients with different genders, ages, educational level and economic level in the urban community of Ningxia southern and northern mountainous areas and Yinchuan City of Ningxia were selected and their depression status was assessed by SDS Depression Scale. Different demographic characteristics of T2DM patients with depression, T2DM population under different depression for targeted psychological intervention. The level of UⅡ in plasma of patients with T2DM was measured by radioimmunoassay and the levels of HbA_ (1C) in plasma were measured by BioRADD10 automatic glycosylated hemoglobin analyzer. The differences of UⅡ and HbA_ (1C) The relationship between the conditions. Results The standard scores of depressive symptoms in female T2DM patients were significantly higher than those in male patients (P <0.05). The depression standard scores of T2DM patients in younger age groups were significantly higher than those in elderly patients (P <0.05), and the depression standard scores were significantly higher in T2DM patients (P <0.05). The depression standard score of obese T2DM patients was significantly higher than that of normal body mass T2DM patients (P <0.05). The level of plasma UⅡ in female T2DM patients was significantly higher than that in male patients (P <0.05). The levels of plasma UⅡ and HbA_ (1C) in depression group were significantly higher than those in non-depression group (P <0.05). Correlation analysis between plasma UⅡand HbA_ (1C) levels and depression in T2DM patients showed that UⅡr = 0.41 and HbA_ (1C) r = 0.39 (P <0.05). Conclusions The distribution of depression in T2DM patients with different demographic characteristics may be significantly different. The level of depression may be positively correlated with the level of UⅡ and HbA 1 (1C) in plasma.