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目的研究大肠癌根治术和术后辅助化疗对患者外周血VEGF-C活性表达的影响。方法用酶联免疫吸附试验(ELISA)定量检测大肠癌患者术前、化疗前及化疗后3个不同时相血清VEGF-C活性。结果样品的VEGF-C吸光度(OD):术前为0.537±0.026,手术后化疗前为0.441±0.023,化疗后为0.387±0.016,手术前后降低幅度为0.096±0.007,化疗前后降低幅度为0.057±0.005,均有统计学意义(P<0.01)。结论大肠癌根治术及术后辅助化疗均可不同程度的降低大肠癌患者外周血VEGF-C的活性。
Objective To study the effect of radical surgery and postoperative adjuvant chemotherapy on the expression of VEGF-C in peripheral blood of patients with colorectal cancer. Methods Serum levels of VEGF-C were measured by enzyme-linked immunosorbent assay (ELISA) before operation, before chemotherapy and after chemotherapy in colorectal cancer patients. Results The VEGF-C absorbance (OD) of the samples was 0.537 ± 0.026 before surgery, 0.441 ± 0.023 before and after chemotherapy, 0.387 ± 0.016 after chemotherapy, 0.096 ± 0.007 before and after surgery, and 0.057 ± before and after chemotherapy 0.005, both statistically significant (P <0.01). Conclusions Radical surgery of colorectal cancer and postoperative adjuvant chemotherapy may reduce the activity of VEGF-C in peripheral blood of patients with colorectal cancer in varying degrees.