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The direct asymmetric three-component reaction of an aromatic (or cinnamic) aldehyde, an amine and a phosphite was investigated by employing chiral BrΦnsted acid. In general, modest to good enantioselectivities (31%–87% ee) could be obtained in acceptable isolated yields (61%–91%) for a series of substrates.
The direct asymmetric three-component reaction of an aromatic (or cinnamic) aldehyde, an amine and a phosphite was investigated by employing chiral Brφnsted acid. In general, modest to good enantioselectivities (31% -87% ee) could be obtained in acceptable isolated yields (61% -91%) for a series of substrates.