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微小RNA(miRNA)是一类长18～25个核苷酸的非编码小分子RNA,能与靶mRNA的3′UTR碱基配对,通过抑制mRNA的翻译或直接使mRNA降解,在转录后水平使基因沉默。miRNA调节的基因调控机制与肿瘤的发生、发展密切相关。Let-7是目前研究最为广泛的miRNA之一。在多种肿瘤中,let-7表达下调,提示let-7必然与肿瘤存在一些重要的联系。本文就对let-7的生物学特性、作用机制与肿瘤的关系及其在肿瘤治疗方面的潜在作用进行综述。
MicroRNAs (miRNAs) are a class of non-coding small RNAs of 18-25 nucleotides in length. They can pair with the 3’UTR of the target mRNA and inhibit the mRNA translation or mRNA degradation directly. At the post-transcriptional level Silencing genes. The gene regulation mechanism of miRNA is closely related to the occurrence and development of tumors. Let-7 is one of the most widely studied miRNAs. In a variety of tumors, let-7 expression down regulation, suggesting that let-7 must have some important relationship with the tumor. This article reviews the biological characteristics of let-7, the mechanism of action and the relationship between the tumor and its potential role in the treatment of cancer.