急性有机磷农药中毒死亡有二个高峰;即在24小时内死亡为第一高峰;2～7天为第二高峰,近年来,由于抢救方法的不断改进,第一死亡高峰的病死率在逐渐下降,而第二死亡高峰(下称二峰)的病死率却不断增加;因此,降低“二峰”病死率已成为临床医师认真研究的课题。一、合理使用解毒剂有机磷农药中毒解毒剂分两类 (一)阿托品为节后胆碱能神经阻滞剂。使用原则是早期、足量、合理用药;既要迅速达到阿托品化、持续给药也要防止过量或中毒。所谓早期:即指诊断确立后,立即用阿托品治疗。也不要因静脉通道未建立而弃用肌注给药。在基层,先肌肉注射,待静脉通道建立后立刻改静脉给药。足量即结合临床,边用药,边观察,边调整剂量,逐渐达到有效治疗量。70年代药用量不足和停药过早的教训现已基本纠正;但对80年代“宁多勿少”的 Acute organophosphorus pesticide poisoning death has two peaks; death within 24 hours as the first peak; 2 to 7 days for the second peak, in recent years, due to the continuous improvement of rescue methods, the first death peak mortality gradually , While the second death peak (hereinafter referred to as the “second peak”) mortality has been increasing; therefore, to reduce the “second peak” mortality has become a serious study of clinicians. First, the rational use of antidote Organophosphorus pesticide poisoning Antidote divided into two categories (a) atropine for the postganglionic cholinergic nerve blockers. Use the principle of early, adequate, rational use of drugs; it is necessary to quickly achieve atropine, continuous administration but also to prevent excessive or poisoning. The so-called early: that refers to the diagnosis established immediately after treatment with atropine. Do not use intramuscular administration because intravenous access is not established. At the grassroots level, the first intramuscular injection, intravenous route to be changed immediately after the intravenous administration. Sufficient to combine clinical, while medication, while observation, while adjusting the dose, and gradually achieve effective treatment. The lessons of under-consumption and premature drug withdrawal in the 1970s have now been basically corrected. However, in the 1980s, “we should not be less”