论文部分内容阅读
目的 考察疏水性聚胺类 pH 敏感凝胶作为长效药物控释载体的性能及影响因素。 方法 以 9 氨基吖啶 (9AA)为模型药物 ,用分光光度法测定不同疏水 /亲水组成的珠状凝胶在不同 pH的药物释放速度。 结果 甲基丙烯酸乙酯 (EMA)与甲基丙烯酸二乙氨基乙酯 (DEA)共聚得到的凝胶 ,在DEA含量仅为 10mol%时仍保持高度的pH 敏感溶胀性质。该凝胶在 pH≥ 6时可完全不释放药物 ,在pH 5的柠檬酸缓冲溶液中的释药时间可持续 32 0d以上。结论 通过选择聚胺类凝胶中适当的疏水性单体及调节凝胶中疏水 /亲水成分的配比 ,有可能按不同释药周期的需要 ,制备用于 pH 敏感长效释药体系的载体
Objective To investigate the properties and influencing factors of hydrophobic polyamine pH-sensitive gels as long-acting drug controlled release carriers. Methods 9 Amino acridine (9AA) was used as a model drug to determine the drug release rate of beads gels with different hydrophobic / hydrophilic compositions at different pHs by spectrophotometry. Results The gel obtained by the copolymerization of ethyl methacrylate (EMA) and diethylaminoethyl methacrylate (DEA) retained a high pH-sensitive swelling property with a DEA content of only 10 mol%. The gel can not release the drug completely at pH≥6, and can be released for more than 320 days in pH 5 citric acid buffer solution. CONCLUSIONS It is possible to prepare pH-sensitive long-acting drug delivery systems by selecting the appropriate hydrophobic monomer in the polyamine gel and adjusting the hydrophobic / hydrophilic components in the gel. Vector