论文部分内容阅读
目的 探讨β内啡肽(βEP)在中枢神经系统(CNS)感染中的变化。方法 用放射免疫法分别测定了45例病毒性脑炎、18例化脓性脑膜炎、6例结核性脑膜炎及19例对照组患儿血浆和脑脊液(CSF)中βEP含量。结果 病毒性脑炎组血浆和CSF中βEP含量分别为(39.9±24.8) ng/L，(44.8±32.6) ng/L，化脓性脑膜炎组分别为(49.9±28.3) ng/L，(62.1±46.9) ng/L，对照组分别为(14.8±6.6) ng/L，(9.8±6.2) ng/L，差异有显著性意义(P<0.01)。结核性脑膜炎组血浆和CSF中βEP分别为(44.1±25.3) ng/L，(55.8±46.2) ng/L，亦明显高于对照组，差异有显著意义(P<0.05)。CNS感染伴神经功能重度障碍组血浆和CSF中βEP分别为(71.7±20.5) ng/L，(92.1±38.8) ng/L，显著高于神经功能轻中度障碍组分别为(47.1±22.8) ng/L，(55.2±32.8) ng/L和对照组(均P<0.01)；神经功能轻中度障碍组血浆和CSF中βEP显著高于对照组(P<0.01)。结论 血浆和CSF中βEP含量增高尤其后者可作为估量脑水肿或急性脑损伤严重程度的参考指标。
Objective To investigate the changes of βendorphin (βEP) in the central nervous system (CNS) infection. Methods The levels of βEP in plasma and cerebrospinal fluid (CSF) of 45 cases of viral encephalitis, 18 cases of purulent meningitis, 6 cases of tuberculous meningitis and 19 cases of control group were determined by radioimmunoassay. Results The contents of βEP in plasma and CSF of patients with viral encephalitis were (39.9 ± 24.8) ng / L and (44.8 ± 32.6) ng / L, respectively, and those in purulent meningitis were (49.9 ± 28.3) ng / L, (62.1 ± 46.9) ng / L in the control group, and (14.8 ± 6.6) ng / L and (9.8 ± 6.2) ng / L in the control group respectively (P <0.01). The levels of βEP in plasma and CSF of tuberculous meningitis were (44.1 ± 25.3) ng / L and (55.8 ± 46.2) ng / L, respectively, which were also significantly higher than those in control group (P <0.05). The values of βEP in plasma and CSF of CNS-infected patients with neurological dysfunction group were (71.7 ± 20.5) ng / L and (92.1 ± 38.8) ng / L, respectively, which were significantly higher than those in mild and moderate neurological dysfunction group (47.1 ± (P <0.01). The levels of βEP in plasma and CSF of patients with neurological mild and moderate dysfunction were significantly higher than those of the control group (P <0.01) . Conclusion Plasma and CSF β EP increased in particular, the latter can be used as a measure of brain edema or acute brain injury severity of the reference index.