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先天性心脏阻滞不常见,约为活产新生儿的1/20,000。其中30％合并心血管畸形,70％为单一病变。本病患儿的母亲常有结缔组织病,系统性红斑狼疮占1/3。1954年Mecuistin首次报道系统性红斑狼疮患者分娩的新生儿有红斑狼疮症状,此后有不少类似报道。Hardy等,总结新生儿红斑狼疮54例,其中31例有心脏阻滞。新生儿红斑狼疮的临床表现常于生后2～3月消退,而心脏阻滞则多为永久性损伤。结缔组织的患者的后代易患先天性心脏阻滞的机理尚不明确。一股认为与母亲的自身抗体通过胎盘引起胎儿心脏传导系统的免
Congenital heart block is uncommon, which is about 1 in 20,000 live births. 30% of them have cardiovascular malformations and 70% are single lesions. The mother of the patient often had connective tissue disease and systemic lupus erythematosus accounted for 1 / 3. 1954 Mecuistin first reported in newborns with systemic lupus erythematosus patients with lupus symptoms, since there are many similar reports. Hardy, etc., concluded 54 cases of neonatal lupus erythematosus, of which 31 cases of heart block. The clinical manifestations of neonatal lupus erythematosus often subside in 2 to 3 months after birth, and heart failure are mostly permanent damage. The mechanism of susceptibility to congenital heart disease in descendants of connective tissue patients is unclear. One thought that the autoantibodies with the mother through the placenta cause fetal cardiac conduction system immunity