本文报道用天然α干扰素(αIFN)治疗两例IFN生物学应答缺陷的延髓脊髓灰质炎患者的结果.例1,16月龄患儿,开始发热,2～3天内出现两腿无力并很快发展成四肢瘫痪和吞咽困难.入院检查发现血及脑脊液(CSF)中无IFN,用植物血凝素(PHA)刺激外周血单核细胞(PBMC),γIFN产量异常砥(12U/ml,PBMC并不处于抗病毒状态.血清中脊髓灰质炎抗体效价为1∶4,拟诊脊髓灰质炎.用IFNα肌肉注射治疗,1×10~6U/天,共16天(最后1周隔日1次).用药的第2天未发现病情进一步恶化:几天后神经系统症状改善,第10天 This article reports the results of two cases of bulbar poliovirus deficient in IFN biological response treated with natural alpha interferon (αIFN) .Example 1. Children aged 16 months, started fever and became weak and fast in 2 to 3 days Developed paralysis and dysphagia of the limbs, and found no IFN in the blood and cerebrospinal fluid (CSF) at admission, peripheral blood mononuclear cells (PBMC) were stimulated with phytohemagglutinin (PHA), and the production of γIFN was abnormal (12U / ml Not in an antiviral state Serum polio antibody titers of 1: 4, the proposed diagnosis of poliomyelitis with intramuscular IFNα treatment, 1 × 10 ~ 6U / day, a total of 16 days (the last 1 weeks after the first day) No further deterioration was found on the second day of treatment: neurological symptoms improved after a few days, and on day 10