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目的探讨院内继发真菌肺部感染与抗生素使用的关系。方法对新疆医科大学第五附属医院呼吸科近期发生肺部真菌感染68例老年患者的临床资料进行回顾性分析。结果本组68例患者痰中共分离培养出真菌156株,其中念珠菌(未细分)39株,白色念珠菌35株,热带念珠菌13株,光滑念珠菌7株,未分型真菌46株,曲霉菌16株;继发下呼吸道真菌感染前2个月内使用抗生素最多达7种,感染前最近1个疗程选用的抗生素,以第三代头孢菌素为主,其余依次为半合成青霉素、氟喹喏酮类等。结论导致院内真菌肺部感染的主要原因是抗生素的不合理使用。
Objective To investigate the relationship between nosocomial secondary fungal lung infection and antibiotic use. Methods The clinical data of 68 elderly patients with pulmonary fungal infection in respiratory department of the Fifth Affiliated Hospital of Xinjiang Medical University were retrospectively analyzed. Results A total of 156 strains of fungi were isolated from sputum of 68 patients, including 39 Candida (not subdivided), 35 Candida albicans, 13 Candida tropicalis, 7 Candida glabra, 46 non-typed fungi , Aspergillus 16 strains; secondary to lower respiratory tract fungal infection within 2 months before the use of antibiotics up to 7 species, the most recent course of infection before the election of a course of antibiotics used to the third generation cephalosporins, followed by the semi-synthetic penicillin , Fluoroquinolone and the like. Conclusions The main cause of fungal lung infections in the hospital is the irrational use of antibiotics.