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在大鼠侧脑室内注射白细胞介素—Ⅰβ(IL—Ⅰβ)后30分钟,观察血液中促肾上腺皮质激素(ACTH)、皮质酮的浓度,建立一个肾上腺皮质轴对免疫因子的反应状态,以此来观察3类中药对这一反应状态是否有不同的影响。结果显示,侧脑室内注射IL—Ⅰβ后血中ACTH、皮质酮明显升高,与国外文献报道相似;补肾中药能使因IL—Ⅰβ诱导而升高了的血中ACTH、皮质酮进一步明显升高;健脾中药也有升高趋势;活血化瘀中药则未见明显差异。
30 minutes after intracerebroventricular injection of interleukin-lβ (IL-Iβ) in rats, observe the concentration of adrenocorticotropic hormone (ACTH) and corticosterone in the blood and establish a response state of the adrenal cortex axis to immune factors. This is to observe whether the three types of Chinese medicine have different effects on this reaction state. The results showed that ACTH and corticosterone in the blood were significantly increased after intracerebro-injection of IL-Iβ, which was similar to that reported in foreign countries; kidney-invigorating herbs can increase the ACTH and corticosterone levels in blood that are elevated due to IL-Iβ induction. High; spleen-enhancing Chinese medicine also has an increasing trend; blood circulation and phlegm medicine has no obvious difference.