目的探讨低颅压综合征的临床特点、诊断及治疗经验。方法回顾性分析11例低颅压综合征患者的临床资料。结果 11例低颅压综合征患者经补液及激素治疗后均痊愈出院。结论低颅压综合征临床表现多样,体位性头痛是其主要的临床特点,腰椎穿刺及头部MRI检查具有诊断价值。 Objective To investigate the clinical characteristics, diagnosis and treatment experience of intracranial hypotension syndrome. Methods The clinical data of 11 patients with low intracranial pressure syndrome were retrospectively analyzed. Results 11 cases of patients with low intracranial pressure syndrome were treated by fluid replacement and hormone therapy were cured and discharged. Conclusions The clinical manifestations of low intracranial pressure syndrome are diverse. Postural headache is the main clinical feature. Lumbar puncture and head MRI have diagnostic value.