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N-乙酰基-丝氨酰-天冬氨酰-赖氨酰-脯氨酸(N-acetyl-seryl-aspartyl-lysyl-proline,AcSDKP)是广泛存在于哺乳动物体内的乙酰化小分子四肽,具有广泛的生理功能。近年来,AcSDKP参与组织器官细胞外基质沉积和纤维化调控的作用与机制越来越受到国内外学者的重视,已有研究发现其对心、肝、肺、肾等器官纤维化有抑制作用,而这些作用与各器官的产纤维细胞关系密切。本文就AcSDKP对心、肝、肺、肾内的产纤维细胞功能影响的研究进展展开综述。
N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) is an acetylated small molecule tetrapeptide widely found in mammals , With a wide range of physiological functions. In recent years, the role and mechanism of AcSDKP in the regulation of extracellular matrix deposition and fibrosis in tissues and organs has been paid more and more attention by domestic and foreign scholars. It has been found that AcSDKP can inhibit the fibrosis of organs such as heart, liver, lung and kidney, And these effects and the various organs of fibroblasts are closely related. This review summarizes the research progress of the effect of AcSDKP on the function of fibroblasts in heart, liver, lung and kidney.