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目的 探讨西比灵治疗脑出血继发脑水肿的疗效及作用机制。方法 90例脑出血患者随机分为西比灵治疗组 5 0例 ,常规治疗对照组 40例 ,常规治疗组进行常规治疗 ,西比灵治疗组应用常规治疗 +西比灵 5mg ,每晚口服 ,共 2 0天 ,并分别在治疗前、治疗后 3、2 0天进行病情评分及ET 1、NSE测定并与对照组进行疗效对比。结果 (1)西比灵治疗组的临床疗效优于常规治疗组 (P <0 .0 5 ) ;(2 )西比灵治疗后ET 1、NSE浓度明显低于治疗前 (P <0 .0 1) ,随着病程的延长 ,二者血浆含量有下降趋势 ,与脑水肿密切相关。结论 (1)西比灵治疗脑出血继发脑水肿具有肯定疗效 ;(2 )ET 1、NSE血浆浓度测定可能成为脑出血继发脑水肿诊断及疗效评估的客观指标。
Objective To investigate the curative effect and mechanism of xibei ling on cerebral edema secondary to intracerebral hemorrhage. Methods Ninety patients with cerebral hemorrhage were randomly divided into xibiritin treatment group (n = 50), conventional treatment control group (n = 40) and routine treatment group (n = A total of 20 days, and before treatment, respectively, 3,20 days after treatment score and ET 1, NSE determination and control group were compared. Results (1) The clinical effects of Xibeiling treatment group were better than those of the conventional treatment group (P <0.05). (2) The concentrations of ET 1 and NSE in the Xibeiling group were significantly lower than those before treatment 1), with the extension of the course of the plasma levels of both have a downward trend, closely related to cerebral edema. Conclusion (1) The treatment of cerebral hemorrhage with xibei Ling cerebral edema has a positive effect; (2) ET 1, NSE plasma concentrations may be cerebral hemorrhage secondary diagnosis of cerebral edema and curative effect evaluation of objective indicators.