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目的：为探讨多发性硬化ＭＲＩ增强病灶的形态特征、自然寿命、演变规律。方法：对１２例临床诊断的多发性硬化患者每月ＭＲＩ检查１次，６～２８个月的长期追踪，获得２９１个病灶。结果：新增强病灶的大多数在２个月内消失，其半减期为２４ｄ；１０ｍｍ以上的增强病灶，多数随着时间的推移，强化分别由均匀强化演变为环形、点状强化及不强化四个阶段。１０％（２９／２９１）的增强病灶不能被相应的Ｔ２加权像所显示。结论：研究表明，新增强病灶出现后，随着时间推移病灶缩小最后消失，未见扩大或病灶相互融合；Ｔ１增强像在指示新病灶方面较Ｔ２加权像为优。
Objective: To investigate the morphological characteristics, natural life expectancy and evolution of lesions enhanced by MRI in multiple sclerosis. Methods: Twelve patients with multiple sclerosis who were clinically diagnosed were screened by MRI every month and followed up for 6 ~ 28 months. 291 lesions were obtained. Results: The majority of newly diagnosed lesions disappeared in 2 months with a half-period of 24 days. Most of the lesions with lesions longer than 10 mm were evolved from homogenous enhancement to annular shape, with or without enhancement four stages. 10% (29/291) of the enhanced lesions can not be displayed by the corresponding T2-weighted images. CONCLUSIONS: The study shows that after the appearance of newly-enhanced lesions, the lesions disappear and disappear with time, and no enlargement or fusion of the lesions occurs. T1-enhanced images are superior to T2-weighted images in indicating new lesions.