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[目的 ]筛选治疗广州管圆线虫病的有效药物。[方法 ]以大白鼠为动物模型 ,人工感染广州管圆线虫第 3期幼虫后分别用伊维菌素、阿苯哒唑、甲苯咪唑和噻嘧啶进行治疗 ,然后解剖检虫、计数、测量 ,用 SPSS统计软件包分析比较 4种药物的疗效。 [结果 ]剂量为 2 0 mg/ kg.d× 6的阿苯哒唑和甲苯咪唑均能完全清除感染鼠体内的广州管圆线虫幼虫 ,而总剂量为 2 8mg/ kg的伊维菌素和 86 0 mg/ kg的噻嘧啶未能使感染鼠的虫数减少 ,也不影响第 1期幼虫的产出时间。 [结论 ]阿苯哒唑和甲苯咪唑对广州管圆线虫幼虫有显著的杀虫效果 ,伊维菌素和噻嘧啶无效。
[Objective] To screen effective drugs for the treatment of angiostrongylus cantonensis in Guangzhou. [Method] With the rat as the animal model, the 3rd instar larvae of A. cantonensis were artificially infected with ivermectin, albendazole, mebendazole and pyrantel, and then dissected and counted, measured, SPSS statistical package analysis and comparison of the efficacy of four drugs. [Result] Albendazole and mebendazole at a dose of 20 mg / kg.d × 6 could completely eliminate the A. cantonensis larvae in infected mice, while the total dose was 28 mg / kg of ivermectin and Cetipyrazine at 86 0 mg / kg did not reduce the number of infected mice and did not affect the first larvae ’s production time. [Conclusion] Albendazole and mebendazole had significant insecticidal effects on A. cantonensis larvae, ivermectin and pyrantel were ineffective.