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常用药物如吗啡、消炎痛、洋地黄毒甙等在多种动物体内有肝肠循环。如给狗服用吗啡后,尿内长时间有吗啡排出,人服用洋地黄毒甙后的蓄积作用也是因为有肝肠循环所致。洋地黄毒甙具有较长的半衰期,实际也依赖于肝肠循环的过程。药理学在药代动力学方面有些问题尚无充分的令人信服的解释,如为什么消胆胺、甲氧氯普胺、新霉素等均能使地高辛血药浓度降低,而红霉素、四环素等能使其血药浓度升高。强心甙类在合用抗生素时易引起强心甙中毒等。
Common drugs such as morphine, indomethacin, digoxigenin and other animals in vivo have enterohepatic circulation. Such as taking morphine for dogs, urine morphine for a long time to discharge, after taking digoxin human accumulation is due to the role of the enterohepatic circulation. Digoxin has a longer half-life, in fact, also depends on the process of enterohepatic circulation. Pharmacology in the pharmacokinetics of some issues there is no convincing explanation, such as why cholestyramine, metoclopramide, neomycin, etc. can make digoxin plasma concentration decreased, and erythromycin Su, tetracycline and other blood concentration can make it. Cardiac glycosides in combination with antibiotics easily lead to cardiac glycoside poisoning.