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目的 :探讨核仁组成区相关嗜银蛋白 (Ag NORs)定量检测在子宫平滑肌瘤良、恶性鉴别诊断中的意义。方法 :采用 Crockr方法对 6 5 2例子宫平滑肌瘤、10例子宫平滑肌肉瘤进行 Ag NORs计数 ,并结合临床病理观察。结果 :子宫平滑肌瘤核内 Ag NORs均数明显低于子宫平滑肌肉瘤 ,经统计学处理 (P<0 .0 1) ,具有显著性差异。典型子宫平滑肌瘤与特殊类型平滑肌瘤中上皮性、富于细胞性 ,怪异细胞性平滑肌瘤 Ag NORs均数未见明显差异(P>0 .0 5 )。典型平滑肌瘤与核分裂相活跃性平滑肌瘤 Ag NORs均数有显著性差异 (P<0 .0 5 )。特殊类型平滑肌瘤中 ,Ag NORs核内均数 >5个 ,颗粒大小不一 ,出现畸形颗粒等应警惕恶性可能。结论 :子宫平滑肌瘤 Ag NORs定量检测并结合组织形态学观察对鉴别子宫平滑肌瘤的良、恶性有重要意义。
Objective: To investigate the significance of the quantitative detection of AgNORs in differential diagnosis of benign and malignant uterine leiomyomas. Methods: Sixty-two cases of uterine leiomyomas and 10 cases of uterine leiomyosarcoma were counted for Ag NORs by Crockr method. Results: The average number of Ag NORs in uterine leiomyoma was significantly lower than that in uterine leiomyosarcoma, which was statistically significant (P <0.01). Typical uterine leiomyoma and special types of leiomyoma epithelial, cell-rich, weird cell leukemia Ag NORs showed no significant difference (P> 0.05). The average number of Ag NORs in typical leiomyoma and mitotic active leiomyoma was significantly different (P <0.05). Special type of leiomyoma, Ag NORs nuclear average> 5, the particle size varies, abnormal particles should be alert to the possibility of malignancy. Conclusion: Quantitative detection of uterine leiomyoma Ag NORs combined with histomorphological observation of uterine leiomyoma benign and malignant have important significance.