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目的 :考察 2 5℃下 2 4h内 ,加替沙星注射液与五种输液配伍的稳定性。方法 :分别采用紫外分光光度法和高效液相色谱法测定配伍后 2 4h不同时间加替沙星含量和降解产物的量 ,同时观察外观和测定pH值。结果 :2 5℃下 2 4h内 ,4种配伍液的外观澄明无色变 ,pH值、主药含量和降解产物均无明显变化。与碳酸氢钠注射液配伍后 ,有气泡产生 ,pH值已超出主药允许范围 ,降解产物有明显增加趋势。结论 :室温 2 4h内 ,加替沙星注射液可以与 4种输液配伍使用 ,与碳酸氢钠注射液不宜配伍使用。
Objective: To investigate the stability of compatibility of gatifloxacin injection with five kinds of transfusion during 24 hours at 25 ℃. Methods: The content of gatifloxacin and the amount of degradation products were determined by UV spectrophotometry and high performance liquid chromatography respectively at 24 hours after compatibility. The appearance and the determination of pH value were also observed. Results: The appearance of the four kinds of compatibility liquid was clear and colorless at 24 ℃ within 2 4 h, pH value, main drug content and degradation products had no obvious changes. With sodium bicarbonate injection compatibility, bubbles, pH value has exceeded the allowable range of the main drug, degradation products increased significantly. CONCLUSION: Gatifloxacin injection can be used in combination with 4 kinds of transfusion solution within 24 hours at room temperature, and should not be used in combination with sodium bicarbonate injection.