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本文报告了在模拟人胃液条件下，头（ＡｌｌｉｕｍｃｈｉｎｅｎｓｉｓＧ．Ｄｏｎ．）和苦瓜（ＭｏｍｏｒｄｉｅａｃｈａｒａｎｔｉａＬｉｎｎ．）对Ｎ－二甲基亚硝胺（ＮＤＭＡ）和Ｎ－二乙基亚硝胺（ＮＤＥＡ）体外合成的阻断作用。结果表明：鲜头汁能明显地阻断ＮＤＭＡ和ＮＤＥＡ的化学合成，而鲜苦瓜汁对ＮＤＭＡ和ＮＤＥＡ的化学合成仅有一定的阻断作用；头经煮沸２０ｍｉｎ和盐腌两周后，其阻断作用大大降低，而同样处理对苦瓜的影响却较小；鲜头升和鲜苦瓜汁的剂量与ＮＤＭＡ和ＮＤＥＡ的合成量呈显著的负相关关系；头阻断亚硝胺合成的主要有效成分并不是抗坏血酸，而苦瓜中抗坏血酸的阻断作用却较大；头和苦瓜阻断亚硝胺合成的机理在于头和苦瓜中的有效成分能消除反应液中的亚硝酸盐
This paper reports the in vitro synthesis of N-dimethylnitrosamine (NDMA) and N-diethylnitrosamine (NDEA) by Allium chinensis G.Don. And Momordieacharantia Linn. Under simulated human gastric fluid conditions Blocking effect. The results showed that fresh head juice could obviously block the chemical synthesis of NDMA and NDEA, while fresh bitter melon juice could only block the chemical synthesis of NDMA and NDEA. After boiled for 20 min and salted for two weeks, The effect of the same treatment on bitter gourd was small. The dose of fresh-head and fresh bitter melon had a significant negative correlation with the synthesis of NDMA and NDEA. The main active components of head-blocked nitrosamines synthesis Is not ascorbic acid, while bitter melon in the blocking effect of ascorbic acid is larger; head and bitter melon block nitrosamine synthesis mechanism is that head and bitter gourd in the active ingredient can eliminate the reaction solution of nitrite