论文部分内容阅读
目前尚未成功地找到一种安全、可靠、实用而不干扰性功能的男性避孕药。作者报导应用促性腺素释放激素的协同剂D-色氨酰~6-脯氨酰~9-N-乙胺-LHRH(D-Trp~6-Pro~9-N-ethylamine-LHRH,LHRH_A)对正常男性垂体—睾丸功能的抑制作用,并提出了LHRH_A避孕作用的可能机制。8例正常成年男性,每天皮下注射LHRH_A59μg,共6～10周。并分别在用药前、用药期间和停药后测定血浆睾酮、LH、FSH、雌二醇、17—羟孕酮和孕酮,同时观察了精子密度与精子活动情况。结果表明,注射LHRH_A后上述激素水平
At present, it has not been successfully found a safe, reliable, practical and non-interfering sexual function of male contraceptives. The authors report that D-Trp ~ 6-Pro ~ 9-N-ethylamine-LHRH (LHRH_A), a synergist of gonadotropin- On normal male pituitary - testicular function, and proposed a possible mechanism of LHRH_A contraception. 8 cases of normal adult male, daily subcutaneous LHRH_A59μg, a total of 6 to 10 weeks. The levels of plasma testosterone, LH, FSH, estradiol, 17-hydroxyprogesterone and progesterone were measured before medication, during medication and after stopping medication respectively. The sperm density and sperm motility were also observed. The results showed that LHRH_A after injection of the above hormone levels