为寻求有效的预防药物耳毒性的方法,Преображенский(1980)曾创用建立耳蜗毒性损害的急性实验模型。许多学者证实耳蜗的细胞膜、介质及血管紊乱在药物耳毒性损害的发生上起重大作用。近年认为前列腺素在神经系统的功能和代谢性反应的发展中有重要意义,在耳毒性损害的发病上也有关系,因此可选用能抑制前列腺素的药物。为此,作者选用消炎痛(indomethacin), In an effort to find an effective drug ototoxicity method, Преображенский (1980) created an acute experimental model for the establishment of cochlear toxicity lesions. Many scholars have confirmed that the cochlear cell membrane, media and vascular disorders play a major role in the occurrence of drug ototoxicity. In recent years, prostaglandins have been implicated in the development of nervous system functions and metabolic responses. They are also related to the pathogenesis of ototoxicity, so prostaglandins can be used as drugs. To this end, the author chose indomethacin,