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目的探讨丹参对早期慢性肾功能衰竭(CRF)患者的肾保护作用。方法63例CRF患者随机分为对照组(31例)和治疗组(32例),对照组用厄贝沙坦治疗,治疗组用丹参+厄贝沙坦洽疗,疗程均为6个月。检测并比较治疗前后的血尿素氮(BUN)、血清肌酐(Cr)、总胆固醇(TC),甘油三酯(TG)和尿蛋白。结果两组患者的肾功能、尿蛋白和血脂均有明显改善,治疗组明显优于对照组。结论丹参能够有效的降低CRF患者的尿蛋白水平,改善血脂代谢紊乱。
Objective To explore the renal protective effect of radix salviae miltiorrhizae on early chronic renal failure (CRF). Methods Sixty-three patients with CRF were randomly divided into control group (n = 31) and treatment group (n = 32). The control group was treated with irbesartan. The treatment group received salvia miltiorrhiza plus irbesartan for 6 months. Blood urea nitrogen (BUN), serum creatinine (Cr), total cholesterol (TC), triglyceride (TG) and urinary protein were detected and compared before and after treatment. Results The renal function, urinary protein and lipids in both groups were significantly improved, and the treatment group was significantly better than the control group. Conclusion Salvia can effectively reduce the urinary protein in patients with CRF and improve the dyslipidemia.