目的探讨双眼内源性化脓性眼内炎的诊断和治疗。方法报告1例双眼内源性化脓性眼内炎的诊治过程,并复习有关文献。结果1例罕见严重双眼内源性化脓性眼内炎患者,多次误诊,治疗无效,后经正确诊断,并及时采用玻璃体切割及眼内注射等非常规治疗,不仅保住了眼球而且视力恢复良好。结论当双眼葡萄膜炎对激素、抗生素等治疗不敏感时,应当考虑内源性眼内炎的可能,及时的玻璃体切割术,对挽救视力有决定性作用。 Objective To investigate the diagnosis and treatment of endogenous suppurative endophthalmitis in both eyes. Methods One case of endogenous purulent endophthalmitis was diagnosed and reviewed. Results A rare case of severe endogenous purulent endophthalmitis in both eyes was repeatedly misdiagnosed and treated ineffectively. After correct diagnosis, unconventional treatment such as vitrectomy and intraocular injection was adopted, which not only saved the eyeball but also restored the visual acuity . Conclusions When binocular uveitis is not sensitive to the treatment of hormones and antibiotics, the possibility of endogenous endophthalmitis should be considered and the timely vitrectomy is decisive for salvage vision.