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近年研究发现,细胞增生与核仁组成区(AgNORs)数目呈正相关,因此AgNORs的数目也被不同程度地用于判断肿瘤的性质与类型。本研究目的在于确定AgNORs在鉴别牙源性囊肿与单囊性成釉细胞瘤中的价值。 牙源性角化囊肿、残余囊肿、含牙囊肿、单囊性成釉细胞瘤和常规的成釉细胞瘤共15例,将其标本制成切片,用硝酸银溶液染色后进行观察。使用100倍油镜,选择无炎症区域的囊壁衬里上皮,数100个连续的基底细胞胞核中游离的着黑色的AgNORs的数目,得到每一例病变的AgNORs在每个基底细胞中的平均数和标准差,并行统计学处理。结果表明,单囊性成釉细胞瘤的肿瘤性上皮细胞中AgNORs数最少,与其它病变相比有显著性差异(P<0.05),含牙囊肿中AgNORs数显著高于残余囊肿和单囊性成釉细胞瘤的AgNORs数(P<0.05),其它均无显著差异。
Recent studies have found that cell proliferation and the number of nucleolar organizers (AgNORs) is positively correlated, so the number of AgNORs has also been used to determine the extent and nature of the tumor type. The purpose of this study was to determine the value of AgNORs in the identification of odontogenic cysts and unicystic ameloblastomas. Odontogenic keratocyst, residual cyst, dental cyst, unicystic ameloblastoma and conventional ameloblastoma in 15 cases, the specimens made into sections, with silver nitrate solution staining after observation. Using a 100-fold oil lens, the number of blackened AgNORs free of nucleus in the nuclei of the parietal cells in the noninflammatory region was selected to obtain the average number of AgNORs per basal cell for each lesion And standard deviation, parallel statistical processing. The results showed that the number of AgNORs in monocystic ameloblastoma was the smallest, which was significantly different from other lesions (P <0.05). The number of AgNORs in cyst was significantly higher than that of residual cysts and unicystic cysts AgNORs number of ameloblastoma (P <0.05), the other no significant difference.