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目的了解我院的药品不良反应(ADR)的发生特点和一般规律,为促进临床合理用药和药物安全评价提供依据;方法采用回顾性研究对我院搜集的172例药品不良反应报告,分别从人口学特征、药品分类、累及器官或系统及主要临床表现等方面进行统计分析,并对服药时间对于ADR的发生率进行了研究;结果果60岁以上老年人发生的ADR的发生率较高占23.26%;引发ADR的药物中成药制剂居首位,占34.55%;皮肤反应在各个器官系统ADR中占首位,达34.8%;中长期服药(≥1个月)ADR发生率比短期(<1个月)更低。结论 ADR是涉及到多个器官系统的复杂反应,其发生率和药物成分、剂型、给药方式、患者个体差异、依从性以及服药时间等多种因素有关。
Objective To understand the characteristics and general rules of adverse drug reaction (ADR) in our hospital and provide a basis for promoting clinical rational drug use and drug safety evaluation.Methods A retrospective study was conducted on 172 adverse drug reactions reports collected in our hospital from the population The characteristics of the drug, the classification of the drug, organ or system involved and the main clinical manifestations were analyzed statistically. The incidence of ADR was also studied. Results The incidence of ADR in the elderly over 60 years old was 23.26 %. The drug-induced ADRs accounted for 34.55% of the total, while the skin reactions accounted for 34.8% of the total ADRs in various organ systems. The incidence of ADRs in the long-term and medium-term (≥1 months) patients was significantly lower than that in the short term Month) lower. Conclusions ADR is a complex reaction involving multiple organ systems. The incidence of ADR is related to various factors such as drug composition, dosage form, mode of administration, patient individual differences, compliance and medication time.