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消炎痛(Idomethacin)16年前开始试用于临床,现已普遍采用。此药对各种风湿病有效,常有维持量每天200～300毫克。消炎痛口服吸收很好。口服后3小时或用栓剂后约1小时血中浓度达到最高水平,此后,半衰期大约3小时。口服剂量2/3以葡糖醛酸甙形式从肾排出,其余部分则从粪排出。保太松治疗作用与消炎痛相似,口服后12～14小时见效,半裹期4天。 Nacross于1963年报告293例风湿病人,经消炎痛治疗后208例症状减轻,41例因毒性反应停药。他开始每天用50～75毫克,最后增至150毫克,不能
Indomethacin (Idomethacin) 16 years ago began trial for clinical use, is now widely used. The drug is effective on all kinds of rheumatism, often to maintain the amount of 200 to 300 mg per day. Indomethacin oral absorption is good. The blood levels reached their highest level at 3 hours after oral administration or about 1 hour after the suppository, and thereafter, the half-life was about 3 hours. The oral dose of 2/3 is excreted in the form of glucuronides and the rest is excreted from the excrement. Paul effect of treatment with indomethacin similar effect after oral administration of 12 to 14 hours, half-wrapped 4 days. In 1963, Nacross reported 293 patients with rheumatism, 208 relieved symptoms after indomethacin treatment and 41 patients discontinued due to toxic reactions. He started daily with 50 ~ 75 mg, and finally increased to 150 mg, can not