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本文目的是探讨CEA、TSGF、sIL 2R动态及联合测定对结直肠癌术后再发诊断的价值。分别用放免法、生化比色法、ELISA法对 73例结直肠癌根治术后患者进行每 3～ 6月的系统监测 ,随方中位数为 2 7个月 (6～ 5 2个月 )。另有 5 8例再发的患者作为联合检测的研究对象。结果 :(1) 73例术后患者在随访期复发者 15例 ,其中CEA6人 ,TSGF 9人 ,sIL 2R 6人在确诊前 1～ 6月已开始增高 ,另分别有 2人 ,2人和 3人于确诊时也增高 ;(2 )上述标志物两项或三项的联合测定则明显提高对肝外再发诊断的敏感性。而系统的动态监测则大大降低由于其他疾病引起偶尔增高的假阳性率 ,提高了诊断的特异性。故CEA、TSGF及sIL 2R动态和联合测定能较早的发现结直肠癌的再发 ,并能提高其敏感性及特异性。
The purpose of this article is to investigate the dynamic and combined determination of CEA, TSGF, sIL 2R in the diagnosis of colorectal cancer after recurrence. Radioimmunoassay, biochemical colorimetric assay, and ELISA were used to systematically monitor 73 patients with colorectal cancer after radical surgery every 3 to 6 months. The median of the follow-up was 2 7 months (6 to 52 months). . Another 58 patients with recurrence were the subjects of the joint detection study. Results: (1) Of the 73 postoperative patients with recurrence in the follow-up period, 15 were relapsed, of whom 6 were CEA, 9 were TSGF, and 6 were sIL 2R. The increase was from 1 to 6 months before diagnosis, and the other 2 and 2 were respectively. Three people were also diagnosed at the time of diagnosis; (2) The combined determination of two or three of the above markers significantly increased the sensitivity to extrahepatic recurrent diagnosis. The dynamic monitoring of the system greatly reduced the false positive rate caused by other diseases occasionally increased, and improved the diagnostic specificity. Therefore, the dynamic and combined determination of CEA, TSGF, and sIL 2R can early find out the recurrence of colorectal cancer and increase its sensitivity and specificity.