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C型胰岛素抵抗综合征(Insulin rosistance type C syrsdnome),又名C型综合征,A型变异型胰岛素抵抗综合征。最早于1972年Kobayachi提出。目前包括Dunnigen综合征、脂肪萎缩性糖尿病、Werner综合征等[1-3]。1 C型综合征的发生机制目前已证实为胰岛素受体后缺陷。可发生于受体后转导途径的任何环节;胰岛素受体底物(insulin receptor substratel、IRS)、磷脂酰肌醇-3激酶(phosphatidylinositol-Kinase,PI-3K)、磷酯酰肌醇-3、4、5-磷酸依赖性激酶(phosphatidylinositol-3、4、5-phosphate-dependent kinase PI3,4,5P)、蛋白激酶B(protein kirsaseB,PKB)、蛋白激酶C(protein kinase C;PKC)、葡萄糖转运体
Insulin rosistance type C syrsdnome, also known as type C syndrome, type A variant insulin resistance syndrome. As early as 1972 Kobayachi proposed. Currently includes Dunnigen syndrome, lipoatrophy, Werner syndrome [1-3]. 1 The pathogenesis of syndrome C has now been confirmed as a post-insulin receptor deficiency. Can occur in any part of the receptor after the transduction pathway; insulin receptor substrate (IRS), phosphatidylinositol-3 kinase (phosphatidylinositol-Kinase, PI-3K), phosphatidylinositol-3 , Phosphatidylinositol-3,4,5-phosphate-dependent kinase (PI3,4,5P), protein kinase C (PKB), protein kinase C (PKC) Glucose transporter