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作者对115名孕12～16周妇女比较了16,16-双甲基-反式-Δ~2PGE_1甲基酯阴道栓和羊膜外给予PGE_2中止妊娠的研究结果。所有对象根据月经史和临床检查必要时作超声波检查确定孕龄,无妊娠异常、自发性流产、心血管或肺部疾病、变态反应及癫痫病史。经随机分组后阴道栓组为57人,PGE_2组58人。二组年龄,孕龄、体重、身高及其中经产妇人数无显著差异。PGE_2组经宫颈口无菌置入一导管,经导管以 PGE_2100μg/小时羊膜腔外给药,阴道栓组每3小时将一个阴道栓置入后穹窿中,直至胚胎排出、副反应频繁或严重以至停药或直至放置
The authors compared the results of 16,16-bis-methyl-trans-Δ 2 PGE 1 methyl ester vaginal suppository and amniotic fluid administration of PGE 2 in 115 pregnant women aged 12 to 16 weeks. All subjects underwent a sonographic examination to determine gestational age, absence of pregnancy abnormalities, spontaneous abortion, cardiovascular or pulmonary disease, allergy and history of epilepsy based on menstrual history and clinical examination, if necessary. After randomization, 57 in the vaginal suppository group and 58 in the PGE 2 group. There were no significant differences in age, gestational age, weight, height and number of mothers in the two groups. PGE_2 group was aseptically inserted into a catheter via the cervix and administered with PGE_2100μg / h amnioinum via catheter. One vaginal suppository was inserted into the posterior fornix every 3 hours until the embryo was excreted. The side effects were frequent or severe, Stop or until it is placed