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应用特异性酶联免疫吸附法检测５６例狼疮性肾炎（ＬＮ）患者尿中视黄醇结合蛋白（ＲＢＰ）含量。按ＬＮ的临床表现分为五型、活动与非活动期，并参照ＷＨＯ的ＬＮ病理分型，结合我院对小管间质分型标准进行综合分级评分。结果显示：各型尿ＲＢＰ含量均明显升高。无症状型ＬＮ尿ＲＢＰ含量已有明显升高，提示ＳＬＥ早期已有小管间质受累；肾功能不全型和重叠综合征型尿ＲＢＰ含量显著高于肾炎型和肾病综合征型（Ｐ＜０．０１）；ＬＮ活动期尿ＲＢＰ含量显著高于非活动期（Ｐ＜０．００１）；尿ＲＢＰ含量与ＬＮ小管间质损害总评分呈正相关（ｒ＝０．５３，Ｐ＜０．０１）。说明尿ＲＢＰ含量能敏感地反映ＬＮ小管间质损害的程度，可作为监测ＬＮ活动，指导治疗和判断预后的一项生化指标。
Urinary retinol binding protein (RBP) levels were measured in 56 patients with lupus nephritis (LN) by enzyme-linked immunosorbent assay. According to the clinical manifestations of LN is divided into five types, activities and inactivity, and with reference to WHO’s LN pathological classification, combined with our hospital on the tubulointerstitial typing criteria for a comprehensive graded score. The results showed that: various types of urine RBP levels were significantly increased. RBP content of asymptomatic LN has been significantly increased, suggesting that early SLE tubule involvement; renal insufficiency and overlapping syndrome urine RBP levels were significantly higher than nephritis and nephrotic syndrome (P <0. 01). The urinary RBP content in active LN was significantly higher than that in non-active (P <0.001). The urinary RBP content was positively correlated with the total score of LN interstitial damage (r = 0.53, P <0.01). This shows that the urinary RBP content can sensitively reflect the degree of LN tubulointerstitial damage and can be used as a biochemical indicator to monitor LN activity, guide treatment and prognosis.