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目的：研究ｐ１６ｍＲＮＡ在膀胱癌组织的表达，探讨其对膀胱癌的生物学行为和预后的意义。方法：应用原位杂交技术对５０例膀胱癌和４１例膀胱癌旁组织进行比较，观察ｐ１６ｍＲＮＡ表达情况。结果：（１）膀胱癌组织中ｐ１６ｍＲＮＡ阳性率为３８．００％，明显低于膀胱癌旁组织的阳性率７０．７３％；（２）ｐ１６ｍＲＮＡ表达强度与膀胱癌的临床分级、病理分级、术后复发和生存期均有密切关系；（３）ｐ１６ｍＲＮＡ失表达可能发生在膀胱癌晚期阶段。结论：ｐ１６ｍＲＮＡ在抑制膀胱癌的发展中起了重要作用。
Objective: To study the expression of p16 mRNA in bladder cancer tissues and to explore its significance in the biological behavior and prognosis of bladder cancer. Methods: In situ hybridization was used to compare the expression of p16 mRNA in 50 cases of bladder cancer and 41 cases of bladder cancer adjacent tissues. RESULTS: (1) The positive rate of p16 mRNA in bladder cancer tissues was 38.00%, which was significantly lower than that of the paracancerous tissues (70.73%). (2) The intensity of p16 mRNA expression and bladder grading, pathological grade, and surgery After recurrence and survival are closely related; (3) p16mRNA loss of expression may occur in the late stage of bladder cancer. Conclusion: p16 mRNA plays an important role in inhibiting the development of bladder cancer.