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在动物实验中已证明性腺素固醇激素参与并促进靶组织的生长,从人类乳癌及生殖道肿瘤的发病及激素对这些肿瘤的治疗效果上看也支持这点。靶组织里有激素特异受体这一重要概念的形成是在五十年代末期。大量试验证明激素的作用是由类固醇与其受体复合物所调节的,若组织中缺少受体则对激素不起作用。变形细胞可能有受体但不起反应,这是由于缺少某些反应步骤之故。类固醇受体的发现及其特点提供了对孕激素可产生治疗作用的合理解释,孕激素对人的子宫内膜及子宫内膜肿瘤可降低雌激素受体。受体对激素作用方面的知识非常重要,为探索这方面的知识寻找一些化合物既可与受体结合但又不具激素的活性,
In animal experiments it has been shown that gonadotrophin participates in and promotes the growth of target tissues, as well as from the incidence of human breast and genital tumors and the effect of hormones on these tumors. The formation of an important concept of a hormone-specific receptor in the target tissue occurred in the late fifties. Numerous experiments have shown that hormonal effects are regulated by a steroid-receptor complex, but lacking a receptor in tissues has no effect on hormones. Deformable cells may have receptors but do not react, due to the lack of certain reaction steps. The discovery of steroid receptors and their characteristics provide a reasonable explanation for the therapeutic effect progesterone can produce, and progestins lower estrogen receptors on human endometrium and endometrial tumors. Receptors on the role of hormones is very important knowledge, to explore this knowledge to find some compounds that can be combined with the receptor but not hormone activity,