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目的探讨2型糖尿病(T2DM)患者空腹、餐后血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平的变化及其与胰岛素抵抗的相关性。方法T2DM患者35例,对照组非糖尿病患者30例,分别测定空腹血糖(FPG)、胰岛素(IRI)、TNF-α、IL-6、总胆固醇(TC)及甘油三酯(TG)水平;T2DM组加测餐后血糖、胰岛素、TNF-α、IL-6水平。结果T2DM组的胰岛素抵抗指数(HOMA-IR)、TNF-α、IL-6明显高于对照组(分别P<0.01或<0.05),T2DM组餐后的TNF-α、IL-6与空腹组比较无明显差异(P>0.05)。T2DM组TNF-α与FPG、IRI、HOMA-IR、TG成明显正相关(分别P<0.01或<0.05)。IL-6与各项指标无明显相关性(P>0.05)。结论T2DM患者的TNF-α、IL-6明显高于非糖尿病患者。TNF-α参与胰岛素抵抗的发生。进食引起的血糖、胰岛素水平波动不影响TNF-α、IL-6水平。
Objective To investigate the changes of fasting and postprandial serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels and their correlation with insulin resistance in type 2 diabetes mellitus (T2DM) Methods 35 cases of T2DM patients and 30 cases of non-diabetic patients in the control group were measured fasting blood glucose (FPG), insulin (IRI), TNF-α, IL-6, total cholesterol (TC) and triglyceride (TG) Group plus postprandial blood glucose, insulin, TNF-α, IL-6 levels. Results The levels of HOMA-IR, TNF-α and IL-6 in T2DM group were significantly higher than those in control group (P <0.01 or <0.05, respectively) No significant difference (P> 0.05). TNF-α in T2DM group was positively correlated with FPG, IRI, HOMA-IR and TG (P <0.01 or <0.05, respectively). There was no significant correlation between IL-6 and other parameters (P> 0.05). Conclusion The levels of TNF-α and IL-6 in T2DM patients are significantly higher than those in non-diabetic patients. TNF-α is involved in the development of insulin resistance. Food-induced blood glucose, insulin levels do not affect the fluctuations of TNF-α, IL-6 levels.