艾滋病(AIDS)患者的沙门氏菌菌血症经过临床标准药物(如氨苄青霉素,羟氨苄青霉素和妥布拉霉素)的有效治疗后(血浆浓度>MIC),仍有复发。因从复发和初次感染标本中分离出同一菌株,有研究指出其原因可能是患者细胞免疫缺损。环丙氛哌酸(CPFX)为口服氟喹诺酮类抗生素,它具有高的稳态血浓度与抗沙门氏菌MIC比值。服用后胆汁药物浓度很高,且能有效地穿透巨噬细胞。本研究中的4名患者均为患有AIDS Salmonella bacteremia in AIDS patients still has recurrence after effective treatment (plasma concentration> MIC) of clinically standard drugs such as ampicillin, amoxicillin and tobramycin. Because of the same strain isolated from recurrent and primary infection specimens, studies have shown that the reason may be cellular immune deficiency in patients. Ciprofloxacin (CPFX) is an oral fluoroquinolone antibiotic that has a high steady-state blood concentration to anti-Salmonella MIC ratio. After taking bile drug concentration is high, and can effectively penetrate macrophages. All 4 patients in this study had AIDS