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目的探讨不同HBe Ag状态下血清HBs Ag滴度与病毒载量之间的相关关系。方法从由2 258名慢性乙肝病毒感染者组成的研究队列中随机抽取89名研究对象进行血清HBs Ag滴度与病毒载量相关关系的横断面和纵向分析。结果 HBe Ag阳性组HBs Ag滴度、病毒载量均显著高于HBe Ag阴性组(P<0.001);第一轮血清标本HBs Ag滴度与病毒载量呈正相关关系(r=0.642,P<0.001),这种相关关系均见于HBe Ag阳性组(r=0.449,P=0.013)和HBe Ag阴性组(r=0.300,P=0.018);且这种相关关系也见于第三轮HBe Ag阳性组和阴性组(r=0.782,P<0.001;r=0.279,P=0.028);在第二轮标本中,HBe Ag阳性组HBs Ag滴度与病毒载量呈正相关关系(r=0.625,P=0.001),而这种关系在HBe Ag阴性组接近显著性(r=0.229,P=0.078)。多因素分析表明病毒载量、HBe Ag状态和性别与血清HBs Ag滴度有关。结论血清HBs Ag滴度和HBV病毒载量之间的相关关系在HBe Ag阳性和阴性组之间没有差异。
Objective To investigate the relationship between serum HBsAg titer and viral load in different HBe Ag status. METHODS: A total of 89 randomized cohorts of 2 258 CHB patients were selected for cross-sectional and longitudinal analysis of the relationship between serum HBsAg titer and viral load. Results HBsAg titer and viral load of HBe Ag positive group were significantly higher than those of HBe Ag negative group (P <0.001). HBsAg titer of the first serum sample was positively correlated with viral load (r = 0.642, P < 0.001). These correlations were found in HBe Ag positive group (r = 0.449, P = 0.013) and HBeAg negative group (r = 0.300, P = 0.018) (R = 0.782, P <0.001; r = 0.279, P = 0.028). In the second round, HBsAg titer in HBeAg positive group was positively correlated with viral load (r = 0.625, P = 0.001), but this relationship was close to significant in the HBeAg-negative group (r = 0.229, P = 0.078). Multivariate analysis showed that viral load, HBeAg status and gender were related to serum HBsAg titer. Conclusions The correlation between serum HBsAg titer and HBV viral load was not different between HBeAg-positive and -negative groups.