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目的将光量子疗法（Ｕｌｔｒａｖｉｏｌｅｔｂｌｏｏｄｉｒｒａｄｉｔｉｏｎ，ＵＢＩ）与光动力疗法（Ｐｈｏｔｏｄｙｎａｍｉｃｔｈｅｒａｐｙ，ＰＤＴ）的理论相结合，利用ＵＢＩ的氧效应ＰＤＴ的光敏作用，探讨其对肿瘤放疗的增敏作用。方法在体外将患者自体抗凝血（２００～３００ＭＬ）加入血卟啉衍生物（Ｈｅｍｏｔｏｐｏｒｐｈｙｒｉｎｄｅｒｉｖａｔｉｖｅ，ＨＰＤ），经紫外线照射后，回输给病人。回输给２４小时后，行６０钴或６ＭＶＸ线常规分割放疗，治疗中晚期恶性肿瘤１０４例。结果增敏组ＣＲ４６．２％（４８／１０４），ＰＲ４１．３％（４３／１０４），ＣＲ＋ＰＲ８７．５％（９１／１０４），１，２，３年生存率分别为６２．２％，１９．２％，１４．８％。肺癌增敏组与对照组的ＣＲ＋ＰＲ分别为８１．８％（５４／６６）及４４．７％（３０／６７）。子宫颈癌增敏组ＣＲ１００％（１３／１３），对照组ＣＲ６０％（６／１３）。对照组ＣＲ６０％（６／１３）。结论自血光化学疗法可提高中晚期肿瘤对放疗的敏感性，对肺癌、子宫颈癌的放疗增敏作用尤为显著。
Objective To combine the theory of photon therapy (UBI) with photodynamic therapy (PDT) and explore the sensitizing effect of UTI on the radiosensitivity of tumor radiotherapy using PDT. METHODS: The patient’s autologous anticoagulant (200-300 ML) was added in vitro to hematoporphyrin derivative (HPD), which was irradiated with ultraviolet light and then returned to the patient. After 24 hours of reinfusion, conventional cobalt radiotherapy or 6MVX radiotherapy was performed to treat 104 patients with advanced malignancy. Results In the sensitization group, CR 46.2% (48/104), PR 41.3% (43/104), CR+PR 87.5% (91/104), 1, 2, and 3 year survival rates were 62.2%, 19 .2%, 14.8%. The CR+PR in lung cancer sensitization group and control group was 81.8% (54/66) and 44.7% (30/67), respectively. Cervical cancer sensitization group CR100% (13/13), control group CR60% (6/13). The control group CR 60% (6/13). Conclusion Automated photochemotherapy can improve the sensitivity of radiotherapy in the middle and late stage tumors. The radiosensitization of lung cancer and cervical cancer is particularly significant.