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人类肿瘤生成过程由很多复杂环节组成,其主要现象表现为细胞分裂增殖的失调控生长。细胞分裂都必须按照正常细胞程序的每一个步骤进行才能保证机体的正常运转,细胞周期依赖分子PLK1是调节正常细胞有丝分裂、胞质分裂,以及对DNA受损伤后进行一系列反应调节的重要因子。它在细胞周期中的作用已有多位学者共同认识,当细胞失调控时检测到PLK1存在过量的表达,同时大量研究表明,人类PLK1基因不仅在多种已发现的恶性肿瘤中有此现象,而且在一些肿瘤中,它关系到这些肿瘤的发生发展及预后,被认为其可能成为一种新的肿瘤标志物,还可作为肿瘤定向分子靶向治疗中的一个有效目的基因的靶点,并且近年来对PLK1在肿瘤基因蛋白靶向治疗方面的药物研究开发已经成为学者研究的一个热点方向,该文对近年来PLK1在肿瘤生成中的作用,特别是其与妇科肿瘤关系方面的一些研究进展予以以下阐述。
The process of human tumorigenesis consists of many complex processes, the main phenomenon manifested as the deregulated growth of cell division and proliferation. Cell division must be carried out in every step of the normal cellular process to ensure the normal operation of the body. The cell cycle-dependent molecule PLK1 is an important factor that regulates normal cell mitosis, cytokinesis and regulation of a series of responses after DNA damage. Its role in the cell cycle has many scholars common understanding, when the cell dysregulation detected PLK1 over-expression, while a large number of studies have shown that human PLK1 gene not only in a variety of discovered malignant tumors have this phenomenon, Moreover, in some tumors, it is related to the development and prognosis of these tumors and is considered as a new tumor marker. It may also serve as a target of an effective target gene in tumor-targeted molecular targeted therapy, and In recent years, the research and development of PLK1 in the field of targeted therapy of tumor gene protein has become a hot research direction of scholars. This article has made some researches on the role of PLK1 in tumorigenesis in recent years, especially its relationship with gynecologic oncology Give the following explanation.