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细菌生物膜(BF)是细菌在生长过程中附着于固体表面相互粘连并将其自身微菌落聚集缠绕其中形成的膜样物。BF内的细菌可逃逸机体免疫防御机制,抵御抗菌药物的杀伤作用,是导致感染反复发作、迁延不愈的重要原因之一。目前临床常用的抗菌药物对BF的清除作用有限。研究发现,枯草芽胞杆菌成熟的BF产生两种活性物质———D-氨基酸(D-amino acids)和3,3’-二氨基二丙基胺(norspermidine)能破坏BF的结构,若联合敏感的抗菌药物可达到彻底消除BF的目的。BF分散物质的发现可能成为治疗BF所致感染的新靶标,为临床提供新思路。本文就新近发现的这两种活性物质进行综述。
Bacterial biofilm (BF) is a kind of membrane sample formed when bacteria adhere to the surface of solid and adhere to each other and gather their own micro-colonies during the growth of bacteria. BF bacteria can escape the body’s immune defense mechanism to resist the killing effect of antibacterial drugs is one of the important causes of repeated episodes of infection, delayed healing. At present, antibacterials commonly used in clinical practice have a limited effect on the removal of BF. The results showed that two active substances produced by BF of B. subtilis, D-amino acids and 3,3’-diaminodipropylamine (Norspermidine), could destroy the structure of BF. If combined sensitization Antibacterial drugs can achieve the purpose of the complete elimination of BF. The discovery of BF disperse material may become a new target for the treatment of BF-induced infection, providing new ideas for clinical practice. This article reviews the two newly discovered actives.