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长期酗酒可以诱导脂肪肝的形成,本文旨在研究三七总皂苷对慢性酒精诱导脂肪肝的保护作用及其机理。将小鼠随机分为三组,分别给予含有酒精的Lieber-DeCarli液体饲料,混合200 mg/kg/BW的三七总皂苷的酒精Lieber-DeCarli液体饲料,和对照Lieber-DeCarli液体饲料,连续饲喂8周,结果显示三七总皂苷能够明显地抑制慢性酒精所导致的肝脂质堆积;同时,三七总皂苷可以明显降低血浆甘油三酯水平,血浆ALT和AST酶活力,以及肝组织TNF-α和IL-6水平。三七总皂苷不仅通过下调磷酸化HSL而抑制白色脂肪组织脂解,而且可以抑制肝摄取脂肪酸的关键CD36基因的表达。结果表明三七总皂苷可以通过改善白色脂肪组织的脂质代谢紊乱和降低炎症因子的产生,发挥对慢性酒精性脂肪肝的保护作用。
Long-term alcoholism can induce the formation of fatty liver, the purpose of this paper is to study the protective effect of Panax Notoginseng saponins on chronic alcohol induced fatty liver and its mechanism. The mice were randomly divided into three groups: Lieber-DeCarli liquid diet containing alcohol, Lieber-DeCarli liquid diet containing 200 mg / kg / BW of Panax notoginseng saponin and Lieber-DeCarli liquid diet, The results showed that Panax notoginseng could obviously inhibit hepatic lipid accumulation caused by chronic alcohol. In the meantime, Panax notoginseng saponins could significantly decrease plasma triglyceride, plasma ALT and AST enzyme activities, as well as liver TNF -α and IL-6 levels. Panax notoginseng not only inhibits lipolysis of white adipose tissue by downregulating phosphorylated HSL, but also inhibits the expression of key CD36 gene for hepatic uptake of fatty acids. The results show that Panax notoginseng saponins can play a protective role in chronic alcoholic fatty liver by improving lipid metabolism disorders and reducing the production of inflammatory factors in white adipose tissue.